Our scientists often contribute to academic research and scientific journals. Here’s a sampling of what we’ve had to say.
A physical and genetic map of Cannabis sativa identifies extensive rearrangement at the THC/CBD acid synthase locus
Cannabis sativa is widely cultivated for medicinal, food, industrial, and recreational use, but much remains unknown regarding its genetics, including the molecular determinants of cannabinoid content. Here, we describe a combined physical and genetic map derived from a cross between the drug-type strain ‘Purple Kush’ and the hemp variety ‘Finola’.
Terpene synthases from cannabis sativa
By analyzing the transcriptome of the cannabis hemp variety “Finola,” this project revealed the genes involved at all stages of terpene production. Terpenes are compounds responsible for the wide array of aromas and flavors found in Cannabis, and specific profiles of terpenes may contribute to the medicinal value and differing psychoactive effects observed between varieties…
The genetic structure of marijuana and hemp
The first large-scale genotyping project in cannabis. This study of diverse cannabis germplasm revealed that marijuana and hemp are significantly differentiated at a genome-wide level, and demonstrated that the genetic differences between these categories of cannabis are not limited to THC production. DNA analysis revealed that reported C. sativa and C. indica ancestry, as well…
Identification of olivetolic acid cyclase from cannabis sativa reveals a unique catalytic route to plant polyketides
Proceedings of the National Academy of Sciences of the US
The first intermediate in the cannabinoid biosynthetic pathway is proposed to be olivetolic acid. This research analyzed glandular trichomes from female cannabis flowers (the primary site of cannabinoid biosynthesis) and discovered the enzyme olivetolic acid cyclase responsible for producing olivetolic acid. The identification of this important component of cannabinoid production clarified the cannabinoid pathway and…
The draft genome and transcriptome of cannabis sativa
The first published draft genome assembly and transcriptome of cannabis. This research discovered the exclusive occurrence of Δ9-tetrahydrocannabinolic acid (THCA) synthase in the Purple Kush transcriptome and its replacement by cannabidiolic acid (CBDA) synthase in “Finola,” which may explain why the psychoactive cannabinoid Δ9-tetrahydrocannabinol (THC) is produced at relatively high concentrations in marijuana but not…